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Generic Name: sargramostim (sar GRA moe stim)
Brand Names: Leukine

What is sargramostim?

Sargramostim is a man-made form of a protein that stimulates the growth of white blood cells in your body. White blood cells help your body fight against infection.

Sargramostim is used to increase white blood cells and help prevent serious infection in conditions such as leukemia, bone marrow transplant, and pre-chemotherapy blood cell collection. Sargramostim is for use in adults who are at least 55 years old.

Sargramostim may also be used for purposes not listed in this medication guide.

What is the most important information I should know about sargramostim?

You should not use this medication if you are allergic to sargramostim or to yeast. Sargramostim should not be used within 24 hours before or after you receive chemotherapy or radiation.

Before you receive sargramostim, tell your doctor if you have fluid retention (especially around your lungs), heart disease, high blood pressure, congestive heart failure, bone marrow cancer, a seizure disorder, liver or kidney disease, or a breathing disorder such as COPD or asthma.

Tell your caregiver right away if you feel dizzy, nauseated, light-headed, short of breath, or have a fast heartbeat, chest tightness, or trouble breathing when you inject this medication.

Call your doctor at once if you have any other serious side effects such as fever, chills, sore throat, flu symptoms, mouth sores, easy bruising or bleeding, and swelling or rapid weight gain.

Using sargramostim may increase your risk of developing other cancers. Ask your doctor about your individual risk.

What should I discuss with my healthcare provider before using sargramostim?

You should not use this medication if you are allergic to sargramostim or to yeast. Sargramostim should no
Pronunciation: sar-GRA-moe-stim
Generic Name: Sargramostim
Brand Name: Leukine

Leukine is used for:

Reducing severe, life-threatening, or fatal infections after chemotherapy for acute myelogenous leukemia (AML). It is also used to help increase the success of autologous bone marrow transplant and to help increase survival in patients who have bone marrow transplant failure. It may also be used for other conditions as determined by your doctor.

Leukine is a hematopoietic agent. It works by stimulating production of white blood cells in bone marrow.

Do NOT use Leukine if:

  • you are allergic to any ingredient in Leukine or to yeast products
  • you have certain bone marrow disorders
  • you have received chemotherapy or radiation therapy within the last 24 hours or you will be receiving chemotherapy or radiation therapy within the next 24 hours

Contact your doctor or health care provider right away if any of these apply to you.

Before using Leukine:

Some medical conditions may interact with Leukine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have other types of cancer or unusual growths or tumors
  • if you have a history of fluid retention, irr
sargramostim
Dosage Form: liquid, injection

Rx only

Leukine Description

Leukine®  (sargramostim) is a recombinant human granulocyte-macrophage colony stimulating factor (rhu GM-CSF) produced by recombinant DNA technology in a yeast (S. cerevisiae) expression system. GM-CSF is a hematopoietic growth factor which stimulates proliferation and differentiation of hematopoietic progenitor cells. Leukine is a glycoprotein of 127 amino acids characterized by three primary molecular species having molecular masses of 19,500, 16,800 and 15,500 daltons. The amino acid sequence of Leukine differs from the natural human GM-CSF by a substitution of leucine at position 23, and the carbohydrate moiety may be different from the native protein. Sargramostim has been selected as the proper name for yeast-derived rhu GM-CSF.

The liquid Leukine presentation is formulated as a sterile, preserved (1.1% benzyl alcohol), injectable solution (500 mcg/mL) in a vial. Lyophilized Leukine is a sterile, white, preservative-free powder (250 mcg) that requires reconstitution with 1 mL Sterile Water for Injection, USP or 1 mL Bacteriostatic Water for Injection, USP. Liquid Leukine has a pH range of 6.7 - 7.7 and lyophilized Leukine has a pH range of 7.1 - 7.7.

Liquid Leukine and reconstituted lyophilized Leukine are clear, colorless liquids suitable for subcutaneous injection (SC) or intravenous infusion (IV).

Liquid Leukine contains 500 mcg (2.8 x 106 IU/mL) sargramostim and 1.1% benzyl alcohol in a 1 mL solution. The vial of lyophilized Leukine contains 250 mcg (1.4 x 106 IU/vial) sargramosti

Generic Name: Sargramostim
Class: Hematopoietic Agents
VA Class: BL400
Molecular Formula: C639H1002O196S8
CAS Number: 123774-72-1

Introduction

Biosynthetic hematopoietic agent that affects the proliferation and differentiation of a variety of hematopoietic progenitor cells; a yeast-derived (Saccharomyces cerevisiae) recombinant human granulocyte-macrophage colony-stimulating factor (rHuGM-CSF).1 5 131 132

Uses for Leukine

Autologous and Allogeneic Bone Marrow Transplantation

Acceleration of myeloid recovery in adults with non-Hodgkin’s lymphoma, acute lymphocytic (lymphoblastic) leukemia (ALL), or Hodgkin’s disease undergoing cytotoxic chemotherapy and autologous bone marrow transplantation (BMT).1 5 7 8 12 55 75 77 78 91 96 173 174 196

Acceleration of myeloid recovery in patients undergoing allogeneic BMT from HLA-matched related donors.1 5 21 112 173 Also has been used to accelerate myeloid recovery in patients receiving allogeneic BMT from unrelated donors

Generic Name: sargramostim (Intravenous route)

sar-GRA-moe-stim

Commonly used brand name(s)

In the U.S.

  • Leukine

Available Dosage Forms:

  • Powder for Solution
  • Solution

Therapeutic Class: Hematopoietic

Pharmacologic Class: Colony Stimulating Factor

Uses For Leukine

Sargramostim is a synthetic (man-made) version of a substance that is naturally produced in your body called a colony stimulating factor. It helps the bone marrow to make new white blood cells .

When certain cancer medicines are used to fight cancer cells, they also affect the white blood cells that fight infections. Sargramostim is used to prevent or reduce the risk of infection while you are being treated with cancer medicines. This medicine is also used to help the bone marrow recover after a bone marrow transplantation, and for a process called peripheral blood progenitor cell collection in cancer patients .

This medicine is available only with your doctor's prescription .

Before Using Leukine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatrics-specific problems that would limit the usefulness of sargramostim in children. However, safety and efficacy have not been established in babie

In the US, Leukine (sargramostim systemic) is a member of the drug class colony stimulating factors and is used to treat Aplastic Anemia, Bone Marrow Transplantation, Bone Marrow Transplantation - Failure or Engraftment Delay, Bone Marrow Transplantation - Myeloid Reconstruction and Neutropenia Associated with Chemotherapy.

US matches:

  • Leukine

Ingredient matches for Leukine

Sargramostim

Sargramostim is reported as an ingredient of Leukine in the following countries:

  • United States

International Drug Name Search