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Generic Name: methoxsalen (Injection route)

meth-OX-a-len

Injection route(Solution)

Methoxsalen sterile solution should be used only by physicians who have special competence in the diagnosis and treatment of cutaneous T-cell lymphoma and who have special training and experience in the UVAR(R) or UVAR(R) XTS(TM) Photopheresis System .

Commonly used brand name(s)

In the U.S.

  • Uvadex

Available Dosage Forms:

  • Solution
  • Injectable

Therapeutic Class: Antipsoriatic

Chemical Class: Psoralen

Uses For Uvadex

Methoxsalenbelongs to the group of medicines called psoralens. It is used along with ultraviolet light (found in sunlight and some special lamps) to treat the white blood cells from your blood in a process called photopheresis. The treated white blood cells are returned to your body to control skin problems associated with cutaneous T-cell lymphoma, a cancer of the lymph system.

Methoxsalen is to be administered only by or under the supervision of your doctor or other health care professional.

Before Using Uvadex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of methoxs

methoxsalen
Dosage Form: injection, solution
Uvadex™
(Methoxsalen)
STERILE SOLUTION, 20 mcg/mL

Rx ONLY.

CAUTION: READ THE UVAR™ XTS™ or THERAKOS™ CELLEX™ PHOTOPHERESIS SYSTEM OPERATOR'S MANUAL PRIOR TO PRESCRIBING OR DISPENSING THIS MEDICATION.

Uvadex™ (methoxsalen) Sterile Solution should be used only by physicians who have special competence in the diagnosis and treatment of cutaneous T-cell lymphoma and who have special training and experience in the UVAR™ XTS™ or THERAKOS™ CELLEX™ Photopheresis System. Please consult the appropriate Operator's Manual before using this product.

Uvadex Description

Methoxsalen is a naturally occurring photoactive substance found in the seeds of the Ammi majus (Umbelliferae) plant. It belongs to a group of compounds known as psoralens or furocoumarins. The chemical name of methoxsalen is 9-methoxy-7H-furo[3,2-g][1]-benzopyran-7-one; it has the following structure:

Each mL of Uvadex™ (methoxsalen, 8-methoxypsoralen) Sterile Solution contains methoxsalen 20 mcg, propylene glycol 50 mg, sodium chloride 8 mg, sodium acetate 1.75 mg, ethanol 0.05 mL, glacial acetic acid 0.0012 mL, and Water for Injection q.s. to 1.0 mL.

Uvadex™ is used in combination with the UVAR™ XTS™ Photopheresis System to extracorporeally treat leukocyte enriched buffy coat.

Uvadex - Clinical Pharmacology

Mechanism of action

The exact mechanism of action of methoxsalen is not known. The best-known biochemical reaction of methoxsalen is with DNA. Methoxsalen, upon photoactivation, conjugates and forms covalent bonds with DNA which leads to the formation

In the US, Uvadex (methoxsalen systemic) is a member of the drug class psoralens and is used to treat Cutaneous T-cell Lymphoma.

US matches:

  • Uvadex

Ingredient matches for Uvadex

Methoxsalen

Methoxsalen is reported as an ingredient of Uvadex in the following countries:

  • Germany
  • Switzerland
  • United States

International Drug Name Search