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Pronunciation: eye-KAT-i-bant
Generic Name: Icatibant
Brand Name: Firazyr

Firazyr is used for:

Treating sudden attacks of hereditary angioedema (HAE). It may also be used for other conditions as determined by your doctor.

Firazyr is a bradykinin B2 receptor blocker. It works by blocking bradykinin, a substance which is thought to be responsible for the HAE symptoms of swelling, inflammation, and pain.

Do NOT use Firazyr if:

  • you are allergic to any ingredient in Firazyr

Contact your doctor or health care provider right away if any of these apply to you.

Before using Firazyr:

Some medical conditions may interact with Firazyr. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances

Some MEDICINES MAY INTERACT with Firazyr. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Angiotensin converting enzyme (ACE) inhibitors (eg, lisinopril) because their effectiveness may be decreased by Firazyr

This may not be a complete list of all interactions that may occur. Ask your health care provider if Firazyr may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Firazyr:

Use Firazyr as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Firazyr. Talk to your pharmacist if you have questions about this information.
  • Firazyr may be given as an injection at your doctor's office, hospital, or clinic. If you will be using Firazyr at home, a health care provider will teach you how to use it. Be sure you understand how to use Firazyr. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Use the proper technique taught to you by your doctor. Inject deep under the skin, NOT into muscle.
  • Do not use Firazyr if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • If your symptoms continue, or if they go away and then come back, you may use another dose of Firazyr as directed by your doctor. Wait at least 6 hours between doses.
  • Do not use more than 3 doses in a 24 hour period.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you are unable to use your dose of Firazyr, seek immediate medical attention.

Ask your health care provider any questions you may have about how to use Firazyr.

Important safety information:

  • Firazyr may cause dizziness, drowsiness, or tiredness. These effects may be worse if you take it with alcohol or certain medicines. Use Firazyr with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • If you have an HAE attack that includes your throat (laryngeal attack), use Firazyr and then seek immediate medical attention. Symptoms of a laryngeal attack may include swelling of the mouth, face, lips, throat, or tongue; difficulty swallowing; shortness of breath or trouble breathing; wheezing; or unusual hoarseness. Discuss any questions or concerns with your doctor.
  • Firazyr should be used with extreme caution in CHILDREN younger than 18 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Firazyr while you are pregnant. It is not known if Firazyr is found in breast milk. If you are or will be breast-feeding while you use Firazyr, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Firazyr:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; headache; nausea; pain, bruising, burning, warmth, swelling, numbness, or redness at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fever; severe or persistent burning, pain, swelling, or other irritation at the injection site.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Firazyr side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include itching; redness; symptoms of low blood pressure (eg, fainting, light-headedness, severe or persistent dizziness).

Proper storage of Firazyr:

Store Firazyr in the refrigerator or at room temperature, between 36 and 77 degrees F (2 and 25 degrees C). Store in the original container until you are ready to use it. Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Firazyr out of the reach of children and away from pets.

General information:

  • If you have any questions about Firazyr, please talk with your doctor, pharmacist, or other health care provider.
  • Firazyr is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Firazyr. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012
Database Edition
Copyright 2012 Wolters Kluwer Health, Inc.

More Firazyr resources

  • Firazyr Side Effects (in more detail)
  • Firazyr Use in Pregnancy & Breastfeeding
  • Firazyr Drug Interactions
  • Firazyr Support Group
  • 0 Reviews for Firazyr - Add your own review/rating
  • Firazyr Prescribing Information (FDA)
  • Firazyr Advanced Consumer (Micromedex) - Includes Dosage Information
  • Firazyr Consumer Overview

Compare Firazyr with other medications

  • Hereditary Angioedema

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