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Lupron Depot
Pronunciation: LOO-proe-lide
Generic Name: Leuprolide
Brand Name: Lupron Depot

Lupron Depot is used for:

Treating symptoms of advanced prostate cancer. It may also be used for other conditions as determined by your doctor.

Lupron Depot is a gonadotropin-releasing hormone (GnRH) agonist. It works by decreasing levels of certain hormones produced by the testes and ovaries. This prevents the growth of certain tumors that need these hormones to grow.

Do NOT use Lupron Depot if:

  • you are allergic to any ingredient in Lupron Depot, to GnRH, or to another GnRH agonist (eg, histrelin)
  • you are pregnant, able to become pregnant, or are breast-feeding

Contact your doctor or health care provider right away if any of these apply to you.

Before using Lupron Depot:

Some medical conditions may interact with Lupron Depot. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of diabetes or high blood sugar, urinary problems (eg, a blockage of the bladder or ureters), spinal cord problems, abnormal growths on or near the spinal cord, a certain type of irregular heartbeat (congenital long QT syndrome) or other heart problems (eg, congestive heart failure), blood vessel problems, or a stroke
  • if you have bone problems (eg, weak bones, osteoporosis) or if a family member has had bone problems
  • if you have blood electrolyte problems (eg, low blood magnesium or potassium levels)
  • if you are taking medicines that can weaken the bones, such as anticonvulsants (eg, phenytoin) or corticosteroids (eg, prednisone)
  • if you take any medicine that may increase the risk of a certain type of irregular heartbeat (prolonged QT interval). Check with your doctor or pharmacist if you are unsure if any of your medicines may increase the risk of this type of irregular heartbeat

Some MEDICINES MAY INTERACT with Lupron Depot. Tell your health care provider if you are taking any other medicines, especially any of the following: Antiarrhythmic medicines (eg, amiodarone, quinidine, sotalol) because they may increase the risk of a certain type of irregular heartbeat (prolonged QT interval)

This may not be a complete list of all interactions that may occur. Ask your health care provider if Lupron Depot may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Lupron Depot:

Use Lupron Depot as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Lupron Depot. Talk to your pharmacist if you have questions about this information.
  • Lupron Depot is usually given every month (4 weeks) as an injection at your doctor's office, hospital, or clinic. If you will be using Lupron Depot at home, a health care provider will teach you how to use it. Be sure you understand how to use Lupron Depot. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not use Lupron Depot if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • Do not miss any doses of Lupron Depot. If you miss a dose of Lupron Depot, contact your doctor right away.

Ask your health care provider any questions you may have about how to use Lupron Depot.

Important safety information:

  • Certain hormone levels may increase during the first few weeks of treatment with Lupron Depot. This may cause you to experience worsening symptoms or onset of new symptoms (eg, bone pain; blood in the urine; difficulty urinating; burning, numbness, or tingling) during the first few weeks of treatment. Patients with growths on or near the spine or spinal cord, or a blockage of the bladder or ureters may be at greater risk of developing serious and sometimes fatal complications. Contact your doctor if any new or worsened symptoms occur while using Lupron Depot.
  • Lupron Depot lowers the amount of certain hormones in your body. This may cause certain expected side effects to occur, such as changes in breast size, breast soreness or tenderness, testicular changes, decreased sexual ability, hot flashes, or night sweats. Contact your doctor if you have questions or concerns or if you experience any of these side effects.
  • Lupron Depot may cause your bones to weaken or become more prone to fractures, especially if you use Lupron Depot for long periods of time. Contact your doctor if you experience bone pain or if you have concerns regarding changes in bone density.
  • A slight increase in the risk of stroke or serious and sometimes fatal heart problems has been reported with the use of GnRH agonists in men. Although the risk appears to be low, seek immediate medical attention if you experience chest, jaw, or left arm pain; confusion; fainting; numbness of an arm or leg; one-sided weakness; slurred speech; sudden, severe headache or vomiting; or vision changes. Discuss any questions or concerns with your doctor.
  • High blood sugar and an increased risk of the development of diabetes has been reported in men who use GnRH agonists. Patients who already have diabetes may develop trouble controlling their blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • Diabetes patients - Lupron Depot may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • A serious pituitary gland problem (pituitary apoplexy) has rarely been reported with the use of Lupron Depot. Most cases developed within 2 weeks after the first dose. Contact your doctor right away if you experience a sudden headache, vomiting, fainting, eye weakness, inability to move your eyes, mental status changes, or vision changes.
  • Lupron Depot may interfere with certain lab tests, including certain hormone and pituitary gland function tests. Be sure your doctor and lab personnel know you are using Lupron Depot.
  • Lab tests, including blood testosterone levels, prostate-specific antigen (PSA), hemoglobin A1c, blood glucose, and bone density, may be performed while you use Lupron Depot. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Lupron Depot should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Lupron Depot if you are pregnant. It may cause birth defects, or fetal or newborn death if you use it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if Lupron Depot is found in breast milk. Do not breast-feed while using Lupron Depot.

Possible side effects of Lupron Depot:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Breast tenderness; constipation; decreased sexual desire or ability; difficulty sleeping; hot flashes or sweating; infection (fever, chills, sore throat); nausea or vomiting; pain, redness, or swelling at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; burning, numbness, tingling, or weakness; fainting; fast, slow, or irregular heartbeat; mental or mood changes (eg, anxiety, delusions, depression, nervousness); new or worsening bone pain; paralysis; seizures; severe dizziness or light-headedness; severe drowsiness; severe headache; shortness of breath; swelling of the hands, ankles, or feet; symptoms of heart attack (eg, chest, jaw, or left arm pain; numbness of an arm or leg; sudden, severe headache or vomiting; vision changes); symptoms of high blood sugar (eg, drowsiness; fast breathing; flushing; fruit-like breath odor; increased thirst, hunger, or urination); symptoms of stroke (eg, confusion, one-sided weakness, slurred speech, vision changes); trouble urinating or inability to urinate; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Lupron Depot side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Lupron Depot:

Store Lupron Depot at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Lupron Depot out of the reach of children and away from pets.

General information:

  • If you have any questions about Lupron Depot, please talk with your doctor, pharmacist, or other health care provider.
  • Lupron Depot is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Lupron Depot. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012
Database Edition
Copyright 2012 Wolters Kluwer Health, Inc.

More Lupron Depot resources

  • Lupron Depot Side Effects (in more detail)
  • Lupron Depot Use in Pregnancy & Breastfeeding
  • Lupron Depot Drug Interactions
  • Lupron Depot Support Group
  • 24 Reviews for Lupron Depot - Add your own review/rating
  • Lupron Depot Advanced Consumer (Micromedex) - Includes Dosage Information
  • Lupron Depot Prescribing Information (FDA)
  • Leuprolide Prescribing Information (FDA)
  • Eligard Consumer Overview
  • Eligard Prescribing Information (FDA)
  • Leuprolide Acetate Monograph (AHFS DI)
  • Lupron Consumer Overview
  • Lupron Depot-PED Prescribing Information (FDA)
  • Viadur Prescribing Information (FDA)

Compare Lupron Depot with other medications

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