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Generic Name: quinine (Oral route)

KWYE-nine

Oral route(Capsule)

Quinine sulfate use for the treatment or prevention of nocturnal leg cramps may result in serious and life-threatening hematologic reactions, including thrombocytopenia and hemolytic uremic syndrome/thrombotic thrombocytopenic purpura (HUS/TTP). Chronic renal impairment associated with the development of TTP has been reported. The risk associated with quinine sulfate use in the absence of evidence of its effectiveness in the treatment or prevention of nocturnal leg cramps outweighs any potential benefit .

Commonly used brand name(s)

In the U.S.

  • Qualaquin
  • Quinamm
  • Quiphile

Available Dosage Forms:

  • Tablet, Extended Release
  • Tablet
  • Capsule

Therapeutic Class: Musculoskeletal Agent

Chemical Class: Cinchona Alkaloid

Uses For Qualaquin

Quinine is used to treat malaria caused by Plasmodium falciparum. Plasmodium falciparum is a parasite that gets into the red blood cells in the body and causes malaria. Quinine works by killing the parasite or preventing it from growing. This medicine may be used alone or given together with one or more medicines for malaria.

Quinine should not be used to treat night time leg cramps. This medicine may cause very serious unwanted effects and should only be used for patients with malaria.

This medicine is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, quinine is used in certain patients with the following medical conditions:

  • Babesiosis (a parasite infection)

Before Using Qua

Generic Name: quazepam (KWAY ze pam)
Brand Names: Doral

What is quazepam?

Quazepam is in a group of drugs called benzodiazepines (ben-zoe-dye-AZE-eh-peens). Quazepam affects chemicals in the brain that may become unbalanced and cause sleep problems (insomnia).

Quazepam is used to treat insomnia symptoms, such as trouble falling or staying asleep.

Quazepam may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about quazepam?

Quazepam may cause a severe allergic reaction. Stop taking quazepam and get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Take quazepam only when you are getting ready for several hours of sleep. You may fall asleep very quickly after taking the medicine.

Some people using this medicine have engaged in activity such as driving, eating, or making phone calls and later having no memory of the activity. If this happens to you, stop taking quazepam and talk with your doctor about another treatment for your sleep disorder.

Do not use this medication if you are allergic to quazepam or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), clorazepate (Tranxene), diazepam (Valium), lorazepam (Ativan), midazolam (Versed), temazepam (Restoril), or triazolam (Halcion). This medication can cause birth defects in an unborn baby, or withdrawal symptoms in a newborn. Do not use quazepam if you are pregnant.

Before taking quazepam, tell your doctor if you have any breathing problems, kidney or liver disease, or a history of depression, mental illness, suicidal thoughts, or addiction to drugs or alcohol.

Quazepam may be habit-forming and should be used only by the person it was prescribed for. Quazepam should never be share

Quinidine Gluconate
EXTENDED-RELEASE TABLETS USP

Rx only

Quinidine Gluconate Description

Quinidine is an antimalarial schizonticide and an antiarrhythmic agent with Class Ia activity; it is the d-isomer of quinine, and its molecular weight is 324.43. Quinidine Gluconate is the gluconate salt of quinidine; its chemical name is cinchonan-9-ol, 6'-methoxy-, (9S)-, mono-D-gluconate; its structural formula is:

Its empirical formula is C20H24N2O2 • C6H12O7, and its molecular weight is 520.58, of which 62.3% is quinidine base.

Each Quinidine Gluconate extended-release tablet contains 324 mg of Quinidine Gluconate (202 mg of quinidine base) in a matrix to provide extended-release; the inactive ingredients include corn starch, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, povidone, silicon dioxide, and sodium alginate.

This product complies with USP Drug Release Test 5.

Quinidine Gluconate - Clinical Pharmacology

Pharmacokinetics and Metabolism

The absolute bioavailability of quinidine from Quinidine Gluconate is 70 to 80%. Relative to a solution of quinidine sulfate, the bioavailability of quinidine from Quinidine Gluconate is reported to be 1.03. The less-than-complete bioavailability is thought to be due to first-pass elimination by the liver. Peak serum levels generally appear 3 to 5 hours after dosing; when the drug is taken with food, absorption is increased in both rate (27%) and extent (17%). The rate and extent of absorption of quinidine from Quinidine Gluconate are not significantly affected by the coadministration of an aluminum-hydroxide antacid. The rate of absorption of quinidine following the ingestio

Generic Name: guaifenesin and pseudoephedrine (gwye FEN e sin, SOO doe ee FED rin)
Brand Names: Altarussin PE, Ambifed, Ambifed-G, Biotuss PE, Congestac, D-Feda II, Despec-SR, Dynex, Entex PSE, ExeFen, ExeFen-IR, Guiatex II SR, Levall G, Maxifed, Maxifed-G, Medent LD, Medent-LDI, Mucinex D, Mucinex D Max Strength, Nasabid SR, Nasatab LA, Nomuc-PE, Poly-Vent, Poly-Vent IR, Poly-Vent, Jr., Pseudatex, Pseudo GG, Pseudo GG TR, Pseudo Max, Q-Tussin PE, Respaire-120 SR, Respaire-30, Respaire-60 SR, Robitussin PE, Robitussin Severe Congestion, Ru-Tuss Jr., Sinutab Non Drying, Stamoist E, SudaTex-G, Tenar PSE, Touro LA, Touro LA-LD, Triaminic Softchews Chest Congestion, We Mist II LA, We Mist LA

What is Q-Tussin PE (guaifenesin and pseudoephedrine)?

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of guaifenesin and pseudoephedrine is used to treat stuffy nose, sinus congestion, and cough caused by allergies or the common cold.

Guaifenesin and pseudoephedrine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Q-Tussin PE (guaifenesin and pseudoephedrine)?

Do not give this medication to a child younger than 4 years old. Alwayss ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the

KWIN-i-deen

Oral route(Tablet, Extended Release)

Many trials of antiarrhythmic therapy for non-life threatening arrhythmias, has resulted in increased mortality; the risk of active therapy is probably greatest in patients with structural heart disease. In the case of quinidine used to prevent or defer recurrence of atrial flutter/fibrillation, meta-analysis data has shown that the mortality associated with the use of quinidine was more than three times greater than placebo. Another meta-analysis showed that in patients with various non-life-threatening ventricular arrhythmias, the mortality associated with the use of quinidine was consistently greater than that associated with the use of any of a variety of alternative antiarrhythmics .

Oral route(Tablet)

Many trials of antiarrhythmic therapy for non-life threatening arrhythmias, has resulted in increased mortality; the risk of active therapy is probably greatest in patients with structural heart disease. In the case of quinidine used to prevent or defer recurrence of atrial flutter/fibrillation, meta-analysis data has shown that the mortality associated with the use of quinidine was more than three times greater than placebo. Another meta-analysis showed that in patients with various non-life-threatening ventricular arrhythmias, the mortality associated with the use of quinidine was consistently greater than that associated with the use of any of a variety of alternative antiarrhythmics .

Commonly used brand name(s)

In the U.S.

  • Cardioquin
  • Quinaglute
  • Quinalan
  • Quinidex Extentabs

Available Dosage Forms:

  • Tablet
  • Tablet, Extended Release
  • Capsule
  • Solution

Therapeutic Class: Antiarrhythmic, Group IA

Chemical Class: Cinchona Alkaloid

Uses For quinidine

Quinidine is used to treat

Generic Name: aminophylline (Oral route)

am-i-NOF-i-lin

Commonly used brand name(s)

In the U.S.

  • Norphyl
  • Phyllocontin

In Canada

  • Quibron-T

Available Dosage Forms:

  • Tablet, Extended Release
  • Tablet
  • Solution

Therapeutic Class: Bronchodilator

Chemical Class: Theophylline

Uses For Quibron-T

Aminophylline is used together with other medicine to treat the symptoms of asthma, bronchitis, emphysema, and other lung diseases.

Aminophylline belongs to a group of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

This medicine is available only with your doctor's prescription.

Before Using Quibron-T

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of aminophylline in children. However, children younger than 1 year of age are more likely to have serious side effects, which may require caution and an adjustment in the dose for patients receiving aminophylli

kwe-TYE-a-peen FUE-ma-rate

Oral route(Tablet;Tablet, Extended Release)

Elderly patients with dementia-related psychosis treated with atypical antipsychotic drugs are at an increased risk of death compared to placebo. Although the causes of death were varied in clinical trials, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Not approved for the treatment of patients with dementia-related psychosis. Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults in short-term studies with major depressive disorder (MDD) and other psychiatric disorders. Short term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. This risk must be balanced with the clinical need. Monitor patients closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Regular strength tablets not approved for use in patients under 10 years of age ; extended-release tablets not approved for use in patients under 18 years of age .

Commonly used brand name(s)

In the U.S.

  • Seroquel
  • Seroquel XR

Available Dosage Forms:

  • Tablet
  • Tablet, Extended Release

Therapeutic Class: Antipsychotic

Chemical Class: Quetiapine

Uses For quetiapine

Quetiapine is u

kwin-ue-PRIS-tin, dal-foe-PRIS-tin

Intravenous route(Powder for Solution)

Quinupristin/dalfopristin has been approved for marketing in the United States for vancomycin-resistant Enterococcus faecium (VREF) bacteremia under FDA's accelerated approval regulations that allow marketing of products for use in life-threatening conditions when other therapies are not available. Approval of this indication is based upon quinupristin/dalfopristin’s ability to clear VREF from the bloodstream, with clearance of bacteremia considered to be a surrogate endpoint. There are no results from well-controlled clinical studies that confirm the validity of this surrogate marker .

Commonly used brand name(s)

In the U.S.

  • Synercid

Available Dosage Forms:

  • Powder for Solution

Therapeutic Class: Antibiotic

Chemical Class: Streptogramin

Uses For quinupristin and dalfopristin

Quinupristin and dalfopristin injection is used to treat infections of the skin and the blood. It may also be used for other conditions as determined by your doctor. It is given by injection and is used mainly for serious infection for which other medicine may not work.

Quinupristin and dalfopristin belong to the family of medicine called antibiotics. Antibiotics are medicines used in the treatment of infections caused by bacteria. They work by killing bacteria or preventing their growth. Quinupristin and dalfopristin will not work for colds, flu, or other virus infections.

quinupristin and dalfopristin is available only with your doctor's prescription.

Before Using quinupristin and dalfopristin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For quinupristin and dalfopristin

Class: Streptogramins
VA Class: AM900
Chemical Name: (S) - 4 - [4 - (Dimethylamino) - N - methyl - l - phenylalanine] - 5 - [5 - [(1 - azabicyclo[2.2.2]oct - 3 - ylthio)methyl] - 4 - oxo - l - 2 - piperidinecarboxylic acid]-virginiamycin
Molecular Formula: C53H67N9O10S
CAS Number: 120138-50-3
Brands: Synercid

  • Indication for treatment of serious or life-threatening infections associated with vancomycin-resistant Enterococcus faecium (VREF) bacteremia is based on FDA's accelerated review process that allows marketing of products for use in life-threatening conditions when other therapies are not available.1 Approval for this indication is based on analysis of surrogate markers of response (i.e., clearance of bacteremia) rather than clinical end points such as cure of infection or survival.1

Introduction

Antibacterial; fixed combination of quinupristin and dalfopristin, 2 semisynthetic streptogramin (synergistin) antibiotics that act synergistically against susceptible gram-positive bacteria.1 2 3 4 5

Uses for Quinupristin and Dalfopristin

Vancomycin-resistant Enterococcus faecium Infections

Treatment of serious or life-threatening infections caused by susceptible vancomycin-resistant Enterococcus faecium (VREF), including infections associated with VREF bacteremia.1 2 3 4 6 7

quinapril hydrochloride and hydrochlorothiazide
Dosage Form: tablets

Quinaretic®


(Quinapril Hydrochloride and Hydrochlorothiazide Tablets) 8263-07

Rx Only

BOXED WARNING

USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, Quinaretic should be discontinued as soon as possible. See WARNINGS: Fetal/Neonatal Morbidity and Mortality.

Quinaretic Description

Quinaretic is a fixed-combination tablet that combines an angiotensin-converting enzyme (ACE) inhibitor, quinapril hydrochloride, and a thiazide diuretic, hydrochlorothiazide.

Quinapril hydrochloride is chemically described as [3S-[2[R*(R*)], 3R*]] - 2 - [2 - [[1 - (ethoxycarbonyl) - 3 - phenylpropyl]amino] - 1 - oxopropyl] - 1,2,3,4 - tetrahydro - 3 - isoquinolinecarboxylic acid, monohydrochloride. Its empirical formula is C25H30N2O5.HCl and its structural formula is:

M.W. = 474.98

Quinapril hydrochloride is a white to off-white amorphous powder that is freely soluble in aqueous solvents.

Hydrochlorothiazide is chemically described as: 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H8ClN3O4S2 and its structural formula is:

M.W. = 297.72

Hydrochlorothiazide is a white to off-white, crystalline powder which is slightly soluble in water but freely soluble in sodium hydroxide solution.

Quinaretic is available for oral use as fixed combination tablets in three strengths of quinapril with hydrochlorothiazide: 10 mg with 12.5 mg (Quinaretic 10/12.5), 20 mg with 12.5 mg (Quinar

succinylcholine chloride
Dosage Form: injection, solution
Quelicin™
SUCCINYLCHOLINE CHLORIDE
INJECTION, USP

A short-acting depolarizing skeletal muscle relaxant.

Fliptop Vial

Rx only

WARNING

RISK OF CARDIAC ARREST FROM HYPERKALEMIC RHABDOMYOLYSIS

There have been rare reports of acute rhabdomyolysis with hyperkalemia followed by ventricular dysrhythmias, cardiac arrest and death after the administration of succinylcholine to apparently healthy pediatric patients who were subsequently found to have undiagnosed skeletal muscle myopathy, most frequently Duchenne’s muscular dystrophy.

This syndrome often presents as peaked T-waves and sudden cardiac arrest within minutes after the administration of the drug in healthy appearing pediatric patients (usually, but not exclusively, males, and most frequently 8 years of age or younger). There have also been reports in adolescents.

Therefore, when a healthy appearing infant or child develops cardiac arrest soon after administration of succinylcholine, not felt to be due to inadequate ventilation, oxygenation or anesthetic overdose, immediate treatment for hyperkalemia should be instituted. This should include administration of intravenous calcium, bicarbonate, and glucose with insulin, with hyperventilation. Due to the abrupt onset of this syndrome, routine resuscitative measures are likely to be unsuccessful. However, extraordinary and prolonged resuscitative efforts have resulted in successful resuscitation in some reported cases. In addition, in the presence of signs of malignant hyperthermia, appropriate treatment should be instituted concurrently.

Since there may be

Pronunciation: koe-LES-teer-a-meen
Generic Name: Cholestyramine
Brand Name: Examples include Prevalite and Questran

Questran Powder is used for:

Lowering blood cholesterol levels. It is used along with changes in diet. It is used to relieve itching caused by partial biliary obstruction. It may also be used for other conditions as determined by your doctor.

Questran Powder is a bile acid sequestrant/anion-exchange resin. It works by increasing the removal of bile acids from the body. As the body loses bile acids, it replaces them by converting cholesterol from the blood to bile acids. This causes the blood level of cholesterol to decrease.

Do NOT use Questran Powder if:

  • you are allergic to any ingredient in Questran Powder
  • you have a complete obstruction of your biliary tract, severe constipation (eg, impacted feces), high blood chloride levels, or certain types of elevated blood lipid levels (type III, IV, or V hyperlipidemia)
  • if you are taking mycophenolate

Contact your doctor or health care provider right away if any of these apply to you.

Before using Questran Powder:

Some medical conditions may interact with Questran Powder. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
Pronunciation: kap-SAY-sin
Generic Name: Capsaicin
Brand Name: Qutenza

Qutenza Patch is used for:

Treating a certain type of nerve pain caused by the shingles (postherpetic neuralgia). It may also be used for other conditions as determined by your doctor.

Qutenza Patch is a TRVP1 channel agonist. It works by decreasing certain pain receptors on some nerve endings.

Do NOT use Qutenza Patch if:

  • you are allergic to any ingredient in Qutenza Patch

Contact your doctor or health care provider right away if any of these apply to you.

Before using Qutenza Patch:

Some medical conditions may interact with Qutenza Patch. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have broken or damaged skin at the application site
  • if you have a history of high blood pressure, other heart problems, or recent heart attack or stroke

Some MEDICINES MAY INTERACT with Qutenza Patch. However, no specific interactions with Qutenza Patch are known at this time.

Ask your health care provider if Qutenza Patch may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Qutenza Patch:

Use Qutenza Patch as

Generic Name: theophylline (Oral route)

thee-OF-i-lin

Commonly used brand name(s)

In the U.S.

  • Elixophyllin
  • Norphyl
  • Phyllocontin
  • Quibron-T
  • Quibron-T/SR
  • Theo-24
  • TheoCap
  • Theochron
  • Theo-Dur
  • Theo-Time
  • Truxophyllin
  • Uniphyl

Available Dosage Forms:

  • Solution
  • Tablet, Extended Release, 12 HR
  • Tablet
  • Capsule, Extended Release, 24 HR
  • Capsule, Extended Release
  • Tablet, Extended Release
  • Capsule, Extended Release, 12 HR
  • Syrup
  • Capsule
  • Tablet, Extended Release, 24 HR
  • Elixir
  • Tablet, Enteric Coated

Therapeutic Class: Bronchodilator

Chemical Class: Methylxanthine

Uses For Quibron-T/SR

Theophylline is used together with other medicines to treat the symptoms of asthma, bronchitis, emphysema, and other lung diseases.

Theophylline belongs to a group of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.

This medicine is available only with your doctor's prescription.

Before Using Quibron-T/SR

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals


Dosage Form: injection
Quinidine GLUCONATE INJECTION, USP This product is to be used by the physician or under his/her direction.

Quinidine Description

Quinidine is an antimalarial schizonticide and an antiarrhythmic agent with class 1a activity; it is the d–isomer of quinine and its molecular weight is 324.43. Quinidine gluconate is the gluconate salt of Quinidine; its chemical name is cinchonan–9–ol, 6'–methoxy–, (9S)–, mono–D–gluconate; its structural formula is

its empirical formula is C20H24N2O2•C6H12O7, and its molecular weight is 520.58, of which 62.3% is Quinidine base.

Each vial of Quinidine Gluconate Injection contains 800 mg (1.5 mmol) of Quinidine gluconate (500 mg of Quinidine) in 10 mL of Sterile Water for Injection, 0.005% of edetate disodium, 0.25% phenol, and (as needed) D–gluconic acid ?–lactone to adjust the pH.

Quinidine - Clinical Pharmacology

Pharmacokinetics and Metabolism

After intramuscular injection of Quinidine gluconate, peak serum levels of Quinidine are achieved in a little less than two hours. This time to peak levels is identical to the time measured when Quinidine salts are administered orally.

The volume of distribution of Quinidine is typically 2–3 L/kg in healthy young adults, but this may be reduced to as little as 0.5 L/kg in patients with congestive heart failure, or increased to 3–5 L/kg in patients with cirrhosis of the liver. At concentrations of 2–5 mg/L (6.5–16.2 ?mol/L), the fraction of Quinidine bound to plasma proteins (mainly to ?1–acid glycoprotein and to albumin) is 80–88% in adults and older children, but it is lower in pregnant women, and in infants and neonates it may be as low as 50–

Generic Name: diphenhydramine (DYE fen HYE dra meen)
Brand Names: Aler-Tab, Allergy, Allermax, Altaryl, Benadryl Allergy, Benadryl DF, Benadryl Dye Free Allergy, Benadryl Ultratab, Children's Allergy, Diphen Cough, Diphenhist, Dytuss, PediaCare Children's Allergy, Q-Dryl, Q-Dryl A/F, Siladryl, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleep-ettes, Sleep-ettes D, Sominex Maximum Strength Caplet, Theraflu Thin Strips Multi Symptom, Triaminic Thin Strips Cough & Runny Nose, Unisom Sleepgels Maximum Strength, Valu-Dryl

What is Q-Dryl A/F (diphenhydramine)?

Diphenhydramine is an antihistamine. Diphenhydramine blocks the effects of the naturally occurring chemical histamine in the body.

Diphenhydramine is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.

Diphenhydramine is also used to suppress coughs, to treat motion sickness, to induce sleep, and to treat mild forms of Parkinson's disease.

Diphenhydramine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Q-Dryl A/F (diphenhydramine)?

Use caution when driving, operating machinery, or performing other hazardous activities. Diphenhydramine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking diphenhydramine.

What should I discuss with my healthcare provider before taking Q-Dryl A/F (diphenhydramine)?

Do not take diphenhydramine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading
levonorgestrel and ethinyl estradiol
Dosage Form: tablets
PHYSICIAN LABELING
Quasense®
(Levonorgestrel and Ethinyl Estradiol Tablets USP) 0.15 mg/0.03 mg (91-Day Regimen)
Rx only

Patients should be counseled that this product does not protect against HIV-infection (AIDS) and other sexually transmitted diseases.

DESCRIPTION

Quasense® is an extended-cycle oral contraceptive consisting of 84 white active tablets each containing 0.15 mg of levonorgestrel, a synthetic progestogen and 0.03 mg of ethinyl estradiol, and 7 peach inert tablets (without hormones).

The chemical formula of levonorgestrel USP is 18, 19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17?)-, (-)-, and the chemical formula of ethinyl estradiol USP is 19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17?)-. The structural formulas are as follows:

C21H28O2   MW: 312.4              C20H24O2   MW: 296.4

Each white active tablet contains the following inactive ingredients: croscarmellose sodium NF, lactose monohydrate NF, magnesium stearate NF, microcrystalline cellulose NF, and povidone USP. Each peach inert tablet contains the following inactive ingredients: anhydrous lactose NF, FD&C yellow #6 Lake, lactose monohydrate NF, magnesium stearate NF, and microcrystalline cellulose NF.

CLINICAL PHARMACOLOGY

Mode of Action

Combination oral contraceptives act by suppression of gonadotropins. Although the primary mechanism of this action is inhibition of ovulation, other alterations include


Dosage Form: tablet
Quinapril Hydrochloride and Hydrochlorothiazide Tablets
Rx Only

USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, quinapril HCl and hydrochlorothiazide tablets should be discontinued as soon as possible. See WARNINGS: Fetal/Neonatal Morbidity and Mortality.

DESCRIPTION

Quinapril HCl and hydrochlorothiazide tablets are fixed-combination tablets that combine an angiotensin-converting enzyme (ACE) inhibitor, quinapril hydrochloride, and a thiazide diuretic, hydrochlorothiazide.

Quinapril hydrochloride USP is chemically described as [3S-[2[R*(R*)], 3R*]]-2-[2-[[1-(ethoxycarbonyl)-3-phenylpropyl] amino]-1-oxopropyl]-1, 2, 3, 4-tetrahydro-3-isoquinolinecarboxylic acid, monohydrochloride. Its empirical formula is C 25H 30N 2O 5. HCl and its structural formula is:

Quinapril hydrochloride USP is a white to off-white amorphous powder that is freely soluble in aqueous solvents.

Hydrochlorothiazide USP is chemically described as: 6-Chloro-3, 4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C 7H 8CIN 3O 4S2 and its structural formula is:

Hydrochlorothiazide USP is a white to off-white, crystalline powder which is slightly soluble in water but freely soluble in sodium hydroxide solution.

Quinapril HCl and hydrochlorothiazide tablets are available for oral use as fixed combination tablets in three strengths of quinapril with hydrochlorothiazide: 10 mg with 12.5 mg (quinapril HCl and hydrochlorothiazide 10/12.5), 20 mg with 12.5 mg (quinapril HCl and hydrochlorothiazide 20/1

Class: Atypical Antipsychotics
VA Class: CN709
Chemical Name: (E)-2-Butenedioate-2-[2-(4-dibenzo[b,f] [1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]-ethanol (2:1) (salt)
Molecular Formula: (C21H25N3O2S)2C4H4O4
CAS Number: 111974-72-2
Brands: Seroquel

Special Alerts:

[Posted 02/22/2011] ISSUE: FDA notified healthcare professionals that the Pregnancy section of drug labels for the entire class of antipsychotic drugs has been updated. The new drug labels now contain more and consistent information about the potential risk for abnormal muscle movements (extrapyramidal signs or EPS) and withdrawal symptoms in newborns whose mothers were treated with these drugs during the third trimester of pregnancy.

The symptoms of EPS and withdrawal in newborns may include agitation, abnormally increased or decreased muscle tone, tremor, sleepiness, severe difficulty breathing, and difficulty in feeding. In some newborns, the symptoms subside within hours or days and do not require specific treatment; other newborns may require longer hospital stays.

BACKGROUND: Antipsychotic drugs are used to treat symptoms of psychiatric disorders such as schizophrenia and bipolar disorder.

RECOMMENDATION: Healthcare professionals should be aware of the effects of antipsychotic medications on newborns when the medications are used during pregnancy. Patients should not stop taking these medications if they become pregnant without talking to their healthcare professional, as abruptly stopping antipsychotic medicat

Generic Name: quetiapine (kwe TYE a peen)
Brand Names: SEROquel, SEROquel XR

What is quetiapine?

Quetiapine is an antipsychotic medicine. It works by changing the actions of chemicals in the brain.

Quetiapine is used to treat schizophrenia in adults and children who are at least 13 years old.

Quetiapine is used to treat bipolar disorder (manic depression) in adults and children who are at least 10 years old.

Quetiapine is also used together with antidepressant medications to treat major depressive disorder in adults.

Extended-release quetiapine (Seroquel XR) is for use only in adults and should not be given to anyone younger than 18 years old.

Quetiapine may also be used for purposes not listed in this medication guide.

What is the most important information I should know about quetiapine?

Never take quetiapine in larger amounts, or for longer than recommended by your doctor. High doses or long-term use of quetiapine can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include tremors or other uncontrollable muscle movements. Quetiapine is not for use in psychotic conditions related to dementia. Quetiapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. Stop using quetiapine and call your doctor at once if you have the following symptoms: very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, uncontrolled muscle movements, feeling light-headed, blurred vision, eye pain, increased thirst and urination, excessive hunger, fruity breath odor, weakness, nausea and vomiting.

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