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Zyclara Cream
Pronunciation: im-I-kwi-mod
Generic Name: Imiquimod
Brand Name: Zyclara

Zyclara Cream is used for:

Treating certain types of skin growths (actinic keratoses) on the face or balding scalp in adults with a normal immune system. It may also be used to treat external genital or perianal warts. It also may be used for other conditions as determined by your doctor.

Zyclara Cream is an immune response modifier. Exactly how it works is not known.

Do NOT use Zyclara Cream if:

  • you are allergic to any ingredient in Zyclara Cream
  • you are also using another cream that contains imiquimod in the same area

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zyclara Cream:

Some medical conditions may interact with Zyclara Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have other types of skin cancer; other skin conditions; broken, damaged, or inflamed skin at the application site; rash at the application site; or warts at the application site other than the genital or anal areas
  • if you have a weakened immune system, HIV infection, an autoimmune disorder (eg, rheumatoid arthritis, lupus), or human papilloma virus (HPV) infection
  • if your skin has not completely healed from surgery or other types of treatment
  • if you sunburn easily or if you will be exposed to sunlight for a prolonged period of time

Some MEDICINES MAY INTERACT with Zyclara Cream. Because little, if any, of Zyclara Cream is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Zyclara Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zyclara Cream:

Use Zyclara Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Zyclara Cream. Talk to your pharmacist if you have questions about this information.
  • A health care provider will teach you how to use Zyclara Cream. Be sure you understand how to use it. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
  • Do not apply Zyclara Cream to any area of the body other than the treatment area. Do not apply it to open wounds or to scraped, blistered, infected, or sunburned skin without first checking with your doctor.
  • Apply Zyclara Cream just before bedtime, unless directed otherwise by your doctor.
  • Wash your hands before and immediately after using Zyclara Cream.
  • Wash your hands and the affected area with mild soap and water before using Zyclara Cream. Allow the area to completely dry (at least 10 minutes) before applying the medicine.
  • Apply a thin layer of medicine to the affected area as directed by your doctor. Gently rub the medicine in until it is no longer visible.
  • Do not wrap or cover the treated area with bandages unless directed by your doctor. Do not wear tight-fitting clothing over the affected area.
  • Leave the medicine on the skin for the prescribed amount of time. Do not bathe or get the area wet until it is time to remove the medicine.
  • Do not leave the medicine on the skin for longer than your doctor tells you. When it is time to remove it, use mild soap and water as directed by your doctor.
  • Throw away any unused medicine that is left in the packet after the first use. Do not store Zyclara Cream in a packet for use at a later time. Throw away unused medicine in a trash container, away from children and pets.
  • Continue to use Zyclara Cream as directed even if your conditions improve. Do not miss any doses.
  • If you miss a dose of Zyclara Cream, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Zyclara Cream.

Important safety information:

  • Zyclara Cream is for external use only. Do not get Zyclara Cream in your eyes, nose, mouth, or in the rectum or on your lips. If you get it in any of these areas, rinse right away with cool water.
  • Do not get Zyclara Cream in the vagina. Pain, swelling, or trouble urinating may occur if you get it in the vagina.
  • Zyclara Cream may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
  • Zyclara Cream may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Zyclara Cream with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Additional skin growths may appear in the treated area while you are using Zyclara Cream. This is normal. Discuss any questions or concerns with your doctor.
  • Do not apply Zyclara Cream to sunburned skin. Wait until your skin has healed before using Zyclara Cream.
  • Zyclara Cream may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Zyclara Cream. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Zyclara Cream may cause minor redness, swelling, flaking, scabbing, or burning at or around the application site. If a severe reaction occurs, wash the medicine off with mild soap and water. Tell your doctor right away if you have a skin reaction that is severe, affects your daily activities, or makes you unable to use Zyclara Cream.
  • Zyclara Cream may cause your skin to become lighter or darker. These effects may be permanent. Discuss any questions or concerns with your doctor.
  • Zyclara Cream may weaken condoms and vaginal diaphragms. This may cause these types of birth control to not work as well in preventing pregnancy. If using Zyclara Cream for genital or perianal warts and using a condom or vaginal diaphragm, do not have sexual contact, including genital, anal, or oral sex, while the medicine is on your skin. Discuss any questions or concerns with your doctor.
  • Lab tests, including skin exams, may be performed while you use Zyclara Cream. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Zyclara Cream should be used with extreme caution in CHILDREN younger than 18 years when treating actinic keratoses and in children younger than 12 years when treating genital or perianal warts; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zyclara Cream while you are pregnant. It is not known if Zyclara Cream is found in breast milk after topical use. If you are or will be breast-feeding while you use Zyclara Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zyclara Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; itching, burning, mild pain, or tenderness at the application site; loss of appetite; redness, dryness, flaking, swelling, or scabbing at the application site; tiredness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bleeding, blistering, drainage, sores, or ulcers at the application site; chest pain; fever, chills, or sore throat; flu-like symptoms (eg, tiredness, nausea, fever, chills, muscle or joint pain); severe irritation or pain at the application site; swollen lymph glands; unusual bruising or bleeding; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Zyclara side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include dizziness; fainting; severe skin irritation.

Proper storage of Zyclara Cream:

Store Zyclara Cream at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zyclara Cream out of the reach of children and away from pets.

General information:

  • If you have any questions about Zyclara Cream, please talk with your doctor, pharmacist, or other health care provider.
  • Zyclara Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Zyclara Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012
Database Edition 12.1.1.002
Copyright 2012 Wolters Kluwer Health, Inc.

More Zyclara resources

  • Zyclara Side Effects (in more detail)
  • Zyclara Use in Pregnancy & Breastfeeding
  • Zyclara Support Group
  • 10 Reviews for Zyclara - Add your own review/rating

Compare Zyclara with other medications

  • Actinic Keratosis
  • Condylomata Acuminata




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