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Zuplenz Soluble Film
Pronunciation: on-DAN-se-tron
Generic Name: Ondansetron
Brand Name: Zuplenz

Zuplenz Soluble Film is used for:

Preventing nausea and vomiting associated with chemotherapy, radiation treatment, or surgery. It may also be used for other conditions as determined by your doctor.

Zuplenz Soluble Film is a serotonin 5-HT3 receptor blocker. It works by blocking a chemical thought to be a cause of nausea and vomiting in certain situations (eg, chemotherapy).

Do NOT use Zuplenz Soluble Film if:

  • you are allergic to any ingredient in Zuplenz Soluble Film
  • you are taking apomorphine
  • you have a certain type of irregular heartbeat (congenital long QT syndrome)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zuplenz Soluble Film:

Some medical conditions may interact with Zuplenz Soluble Film. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have had an allergic reaction to another serotonin 5-HT3 receptor blocker (eg, dolasetron, granisetron)
  • if you have liver problems, heart problems (eg, congestive heart failure, slow or irregular heartbeat, QT prolongation), or electrolyte problems (eg, low potassium or magnesium levels)
  • if you take medicines that may affect your heartbeat. Check with your doctor if you are unsure if any of your medicines may affect your heartbeat

Some MEDICINES MAY INTERACT with Zuplenz Soluble Film. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Apomorphine because the risk of its side effects may be increased by Zuplenz Soluble Film
  • Antineoplastic agents (eg, cyclophosphamide) or tramadol because their effectiveness may be decreased by Zuplenz Soluble Film

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zuplenz Soluble Film may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zuplenz Soluble Film:

Use Zuplenz Soluble Film as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Zuplenz Soluble Film. Talk to your pharmacist if you have questions about this information.
  • Do not remove the film strip from the foil pouch until you are ready to take Zuplenz Soluble Film. Use the film strip immediately after opening the pouch. Do not store the removed film strip for future use.
  • Make sure that your hands are dry when you open the foil pouch.
  • To use Zuplenz Soluble Film, fold the pouch along the dotted line and tear it along the edge. Remove the film strip and place it on the top of your tongue. Once the strip dissolves, it can be swallowed with saliva. Zuplenz Soluble Film may be taken with or without liquid.
  • Do not chew or swallow Zuplenz Soluble Film whole.
  • Wash your hands after you use Zuplenz Soluble Film.
  • To prevent or reduce the possibility of nausea or vomiting, continue taking Zuplenz Soluble Film for the entire time recommended by your doctor even if you do not notice any nausea.
  • If you miss a dose of Zuplenz Soluble Film, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zuplenz Soluble Film.

Important safety information:

  • Zuplenz Soluble Film may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Zuplenz Soluble Film with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Zuplenz Soluble Film should be used with extreme caution in CHILDREN younger than 4 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zuplenz Soluble Film while you are pregnant. It is not known if Zuplenz Soluble Film is found in breast milk. If you are or will be breast-feeding while you use Zuplenz Soluble Film, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Zuplenz Soluble Film:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; headache; tiredness; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; wheezing; unusual hoarseness); chest or jaw pain, numbness of an arm or leg, or sudden, severe headache or vomiting; fainting; fast, slow, or irregular heartbeat; fever; seizures; severe or persistent dizziness; shortness of breath; skin tingling or numbness; stomach pain; trouble urinating; uncontrolled muscle movements; vision changes or loss.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Zuplenz side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include fainting; severe dizziness; slowed, irregular heartbeat; sudden, temporary blindness.

Proper storage of Zuplenz Soluble Film:

Store Zuplenz Soluble Film at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Keep the foil pouches in the carton. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Zuplenz Soluble Film out of the reach of children and away from pets.

General information:

  • If you have any questions about Zuplenz Soluble Film, please talk with your doctor, pharmacist, or other health care provider.
  • Zuplenz Soluble Film is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Zuplenz Soluble Film. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012
Database Edition 12.1.1.002
Copyright 2012 Wolters Kluwer Health, Inc.

More Zuplenz resources

  • Zuplenz Side Effects (in more detail)
  • Zuplenz Use in Pregnancy & Breastfeeding
  • Zuplenz Drug Interactions
  • Zuplenz Support Group
  • 0 Reviews for Zuplenz - Add your own review/rating

Compare Zuplenz with other medications

  • Nausea/Vomiting, Chemotherapy Induced
  • Nausea/Vomiting, Postoperative
  • Nausea/Vomiting, Radiation Induced




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