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Zolpimist Oral Spray
Pronunciation: zole-PI-dem
Generic Name: Zolpidem
Brand Name: Zolpimist

Zolpimist Oral Spray is used for:

Short-term treatment of insomnia (trouble falling asleep).

Zolpimist Oral Spray is a sedative-hypnotic, or sleep medicine. It works by helping to increase certain natural chemicals in the brain that cause sleep.

Do NOT use Zolpimist Oral Spray if:

  • you are allergic to any ingredient in Zolpimist Oral Spray
  • you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zolpimist Oral Spray:

Some medical conditions may interact with Zolpimist Oral Spray. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney or liver problems, lung or breathing problems (eg, chronic obstructive pulmonary disease [COPD], sleep apnea), myasthenia gravis, metabolism problems, heart or blood pressure problems, or very poor health
  • if you have a history of mood or mental problems (eg, depression), suicidal thoughts or behaviors, or alcohol or substance abuse or addiction
  • if you are a child or teenager with a history of attention deficit hyperactivity disorder (ADHD)
  • if you take other medicines to help you sleep (eg, triazolam, zaleplon)

Some MEDICINES MAY INTERACT with Zolpimist Oral Spray. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • HIV protease inhibitors (eg, ritonavir), ketoconazole, or sodium oxybate (GHB) because they may increase the risk of Zolpimist Oral Spray's side effects
  • Rifampin because it may decrease Zolpimist Oral Spray's effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zolpimist Oral Spray may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zolpimist Oral Spray:

Use Zolpimist Oral Spray as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Zolpimist Oral Spray comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Zolpimist Oral Spray refilled.
  • Take Zolpimist Oral Spray by mouth on an empty stomach at least 2 hours after a meal.
  • Zolpimist Oral Spray works very quickly; use Zolpimist Oral Spray right before going to sleep.
  • Use Zolpimist Oral Spray only when you are able to get a full night's sleep (7 to 8 hours).
  • Zolpimist Oral Spray needs to be primed before you use it for the first time. To prime Zolpimist Oral Spray, remove the child-resistant cap and inner clear protective cap. Point the spray opening away from your face and other people. Fully press down on the pump with your finger. Release and let the pump return to starting position. Repeat these steps 4 more times. You should see a fine spray. The medicine is now ready to use.
  • If Zolpimist Oral Spray has not been used within the last 14 days, reprime before using by pressing down 1 time on the pump.
  • To use Zolpimist Oral Spray, open your mouth and hold the container upright with the spray opening pointed directly into your mouth. Press all the way down on the pump and let the medicine spray directly into your mouth over your tongue. If your dose requires a second spray, repeat these steps. Keep the spray away from your eyes. Put the clear protective cap and child-resistant cap back on after each use.
  • Discard Zolpimist Oral Spray after 60 sprays have been used.
  • If you miss a dose of Zolpimist Oral Spray, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. Do not take more than your total daily dose in any 24-hour period.

Ask your health care provider any questions you may have about how to use Zolpimist Oral Spray.

Important safety information:

  • Zolpimist Oral Spray may cause drowsiness, dizziness, blurred vision, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use Zolpimist Oral Spray with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zolpimist Oral Spray; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • When you first start taking Zolpimist Oral Spray, it may have a "carryover" effect on you the next day. Use extreme care while doing anything that requires complete alertness (eg, driving a car).
  • Zolpimist Oral Spray is usually used only for a short period of time. If your symptoms do not get better within 7 to 10 days or if they get worse, check with your doctor.
  • Sleep medicines may cause a special type of memory loss or amnesia. To prevent memory problems, be sure to use Zolpimist Oral Spray only when you are able to get a full night's sleep (7 to 8 hours) before you need to be active again. Be sure to talk to your health care provider if you think you are having memory problems.
  • Some patients taking Zolpimist Oral Spray have performed certain activities while they were not fully awake. These have included sleep-driving, making and eating food, making phone calls, and having sex. Patients often do not remember these events after they happen. Such an event may be more likely to occur if you use a high dose of Zolpimist Oral Spray. It may also be more likely if you drink alcohol or take other medicines that may cause drowsiness while you use Zolpimist Oral Spray. Tell your doctor right away if such an event happens to you.
  • Use Zolpimist Oral Spray with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness or drowsiness.
  • Zolpimist Oral Spray should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed. Children may be more sensitive to Zolpimist Oral Spray's side effects, especially dizziness, headache, and hallucinations.
  • PREGNANCY and BREAST-FEEDING: If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Zolpimist Oral Spray while you are pregnant. Zolpimist Oral Spray may cause prolonged sleep or severe breathing problems in the newborn if you take it during the last weeks of pregnancy, especially if you take it with certain medicines. Zolpimist Oral Spray is found in breast milk. If you are or will be breast-feeding while you use Zolpimist Oral Spray, check with your doctor. Discuss any possible risks to your baby.

When sleep medicines are used every night for more than a few weeks, they may lose their effectiveness to help you sleep. This is known as TOLERANCE. Sleep medicines should usually be used only for short periods of time, such as a few days, and generally no longer than 1 or 2 weeks. If your sleep problems continue, contact your doctor.

When used for longer than a few weeks or at high doses, some people develop a need to continue taking Zolpimist Oral Spray. This is known as DEPENDENCE or addiction. Be sure to tell your doctor if you have been dependent on alcohol, prescription medicines, or street drugs in the past.

If you stop taking Zolpimist Oral Spray suddenly, you may have WITHDRAWAL symptoms. This may include unpleasant feelings. In more severe cases, you may have stomach and muscle cramps, vomiting, sweating, and shakiness. Seizures may rarely occur. If you take Zolpimist Oral Spray for more than 1 to 2 weeks, do not stop taking it without talking to your doctor.

Possible side effects of Zolpimist Oral Spray:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness (including daytime drowsiness); "drugged" feeling; dry mouth; headache; nausea; nose or throat irritation; sluggishness; stomach upset; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, eyes, throat, or tongue; throat closing; unusual hoarseness; severe nausea or vomiting); abnormal thinking; behavior changes; chest pain; confusion; decreased coordination; difficulty swallowing or breathing; fainting; fast or irregular heartbeat; hallucinations; memory problems (eg, memory loss); mental or mood changes (eg, aggression, agitation, anxiety); new or worsening depression; severe dizziness or lightheadedness; shortness of breath; suicidal thoughts or actions; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Zolpimist side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include severe drowsiness or coma.

Proper storage of Zolpimist Oral Spray:

Store Zolpimist Oral Spray at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Avoid prolonged storage above 86 degrees F (30 degrees C). Store Zolpimist Oral Spray upright and away from heat, moisture, and light. Do not store in the bathroom. Do not freeze. Keep Zolpimist Oral Spray out of the reach of children and away from pets.

General information:

  • If you have any questions about Zolpimist Oral Spray, please talk with your doctor, pharmacist, or other health care provider.
  • Zolpimist Oral Spray is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information is summary only. It does not contain all information about Zolpimist Oral Spray. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012
Database Edition
Copyright 2012 Wolters Kluwer Health, Inc.

More Zolpimist resources

  • Zolpimist Side Effects (in more detail)
  • Zolpimist Use in Pregnancy & Breastfeeding
  • Zolpimist Drug Interactions
  • Zolpimist Support Group
  • 2 Reviews for Zolpimist - Add your own review/rating

Compare Zolpimist with other medications

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